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Control products and reagents designed for clinical testing procedures. Ideal for use in performing, calibrating, monitoring, and ensuring the accuracy of diagnostic tests such as immunoassays.
DLin-KC2-DMA (CAS No 1190197-97-7) is a lipid-based nanoparticle formulation commonly used in the field of biomedical research particularly in the delivery of nucleic acids for gene therapy and RNA interference Originating from advancements in lipid nanoparticle technology it functions by encapsulating therapeutic nucleic acids facilitating their cellular uptake and endosomal escape This enables effective delivery into target cells enhancing gene silencing or expression DLin-KC2-DMA exhibits potent activity in vitro typically in the nanomolar to low micromolar range allowing it to be a versatile tool in drug development and screening Its applications extend to various cell models including primary and immortalized cell lines as well as in vivo animal studies where it aids in the evaluation of gene delivery efficacy and safety Experimental concentrations typically depend on the specific research design to ensure optimal results within each study s context
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An ionizable cationic lipid (pKa = 6.7); has been used in the formation of LNPs encapsulating siRNA or plasmid DNA for use in vitro and in vivo; LNPs containing DLin-KC2-DMA selectively accumulate in the liver after i.v. or i.m. administration in mice or localize to the retinal pigment epithelium and Müller glia after subretinal administration; DLin-KC2-DMA-containing LNPs encapsulating F7-targeted siRNA reduce serum Factor VII levels in mice; DLin-KC2-DMA-containing LNPs encapsulating AR-targeted siRNA decrease serum PSA and tumor androgen receptor levels in an LNCaP prostate cancer mouse xenograft model
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1 2-Distearoyl-sn-glycero-3-phosphorylcholine (DSPC) is a phospholipid used in the synthesis of liposomes and lipid nanoparticle (LNP) systems for research related to mRNA vaccines or drug delivery systems
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Lyso-PAF C-16 can be formed by either the action of PAF-AH on PAF C-16,{2626} or by the action of a CoA-independent transacylase on 1-O-hexadecyl-2-acyl-glycerophosphocholine.{240,2098} Lyso-PAF C-16 is a substrate for either PAF C-16 formation by the remodeling pathway{939} or selective acylation with arachidonic acid by a CoA-independent transacylase.{2101}
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